Abstract #2321

Monitoring tumor microenvironment in a mouse model of pancreatic ductal adenocarcinoma using MRI during early stages of tumor development.

Ravneet Vohra¹, Yak-Nam Wang², Helena Son³, Stephanie Totten², and Donghoon Lee¹

¹Radiology, University of Washington, Seattle, WA, United States, ²Applied Physics Laboratory, University of Washington, Seattle, WA, United States, ³Gastroenterology, University of Washington, Seattle, WA, United States

Pancreatic cancer is expected to become the second leading cause of the cancer related deaths in the USA by 2020. A genetically engineered mouse model (KPC) offers an alternative to transplantation models for preclinical therapeutic evaluation as it expresses mutations similar to human pancreatic cell. Magnetic resonance imaging can be used to monitor tumor microenvironment in variety of tumors. The goal of this study was to monitor tumor microenvironment in KPC mouse model during the early stages of tumor development.

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