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Abstract #2322

Glutamine depletion alters choline metabolism and reduces survival of pancreatic cancer cells

Noriko Mori1, Balaji Krishnamachary1, Yelena Mironchik1, and Zaver M. Bhujwalla1,2,3
1The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD, United States, 3Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis due to a combination of late-stage diagnosis and limited response to radiation and chemotherapy. Effective treatments for PDAC are urgently needed. Mutant Kras has been reported as a major cause of glutamine (Gln) addiction in PDAC. Here we investigated the effects of Gln depletion on PDAC cell survival and metabolism. Our data identified Gln as critical for PDAC cell viability. Gln depletion significantly altered choline metabolism in the cell lines investigated.

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