Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis due to a combination of late-stage diagnosis and limited response to radiation and chemotherapy. Effective treatments for PDAC are urgently needed. Mutant Kras has been reported as a major cause of glutamine (Gln) addiction in PDAC. Here we investigated the effects of Gln depletion on PDAC cell survival and metabolism. Our data identified Gln as critical for PDAC cell viability. Gln depletion significantly altered choline metabolism in the cell lines investigated.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords