Abstract #2349

Simultaneous recording of the uptake and conversion of glucose and choline in tumors by deuterium MR

Andor Veltien¹, Sjaak van Asten¹, Nia Ravichandran¹, Robin de Graaf², Henk de Feyter², Jeannette Oosterwijk³, Egbert Oosterwijk³, and Arend Heerschap¹

¹Medical Imaging, Radboud UMC, Nijmegen, Netherlands, ²Radiology and biomedical imaging, Yale University, New Haven, CT, United States, ³Urology, Radboud UMC, Nijmegen, Netherlands

Increased glucose and choline uptake are hallmarks of cancer. In this study we demonstrated that it is possible to follow the uptake and to image the presence of [2H9]choline in tumors after a bolus administration of this compound. In addition we demonstrated the successful performance of DMI simultaneously of [2H9]choline and of [6,6 2H2]glucose. As DMI of glucose uptake and its metabolic conversions has been shown to be feasible in patients, the simultaneous performance of choline DMI next to glucose DMI is an important complementary extension with clinical potential.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.