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Abstract #2349

Simultaneous recording of the uptake and conversion of glucose and choline in tumors by deuterium MR

Andor Veltien1, Sjaak van Asten1, Nia Ravichandran1, Robin de Graaf2, Henk de Feyter2, Jeannette Oosterwijk3, Egbert Oosterwijk3, and Arend Heerschap1
1Medical Imaging, Radboud UMC, Nijmegen, Netherlands, 2Radiology and biomedical imaging, Yale University, New Haven, CT, United States, 3Urology, Radboud UMC, Nijmegen, Netherlands

Increased glucose and choline uptake are hallmarks of cancer. In this study we demonstrated that it is possible to follow the uptake and to image the presence of [2H9]choline in tumors after a bolus administration of this compound. In addition we demonstrated the successful performance of DMI simultaneously of [2H9]choline and of [6,6 2H2]glucose. As DMI of glucose uptake and its metabolic conversions has been shown to be feasible in patients, the simultaneous performance of choline DMI next to glucose DMI is an important complementary extension with clinical potential.

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