Huazheng Dong1, Wenyang Huang2, Xiaodong Ji3, Shuang Xia3, Zhiwei Shen4, Dehui Zou2, Wen Shen3, and Zhiyi Song1
1Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China, Tianjin, China, 2State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China, Tianjin, China, 3Tianjin First Central Hospital Affiliated To Nankai University, Tianjin, China, Tianjin, China, 4Philips healthcare，Beijing， China, Beijing, China
For patients with newly
diagnosed multiple myeloma (MM), red marrow reconversion caused by anemia[1] is
very common. Due to anemia, hyperintense signal on DWI image[2] could
affect the evaluation of MM, because it is very similar with the diffusion signal
in focal lesions. In this study, we aim to evaluate the efficacy prediction of early
treatment response in MM patients with and without anemia based on the tumor
burden score (TBS), ADC value and signal fat fraction (sFF). We found that early
treatment response of MM could be predicted in patients without anemia using TBS,
ADC and sFF acquired by whole body DWI and mDIXON MRI, and anemia is a factor
which must be take into consideration in efficacy evaluation.
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