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Abstract #2354

Prediction of early treatment response in patients with newly diagnosis multiple myeloma using WB-MRI: comparative study with and without anemia

Huazheng Dong1, Wenyang Huang2, Xiaodong Ji3, Shuang Xia3, Zhiwei Shen4, Dehui Zou2, Wen Shen3, and Zhiyi Song1
1Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China, Tianjin, China, 2State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China, Tianjin, China, 3Tianjin First Central Hospital Affiliated To Nankai University, Tianjin, China, Tianjin, China, 4Philips healthcare,Beijing, China, Beijing, China

For patients with newly diagnosed multiple myeloma (MM), red marrow reconversion caused by anemia[1] is very common. Due to anemia, hyperintense signal on DWI image[2] could affect the evaluation of MM, because it is very similar with the diffusion signal in focal lesions. In this study, we aim to evaluate the efficacy prediction of early treatment response in MM patients with and without anemia based on the tumor burden score (TBS), ADC value and signal fat fraction (sFF). We found that early treatment response of MM could be predicted in patients without anemia using TBS, ADC and sFF acquired by whole body DWI and mDIXON MRI, and anemia is a factor which must be take into consideration in efficacy evaluation.

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