Meeting Banner
Abstract #2355

MR Imaging of Murine Tibia for Co-Clinical Studies of Myelofibrosis

Ghoncheh Amouzandeh1, Kevin A Heist1, Dariya I Malyarenko1, Youngsoon Jang1, Tanner Robison1, Christopher Bonham1, Cyrus Amirfazli1, Scott D Swanson1, Gary D Luker1, Brian D Ross1, and Thomas L Chenevert1
1Radiology, University of Michigan, Ann arbor, MI, United States

This study assesses the use of non-invasive MRI to monitor evolution and treatment of Myelofibrosis (MF) in both clinical and pre-clinical settings to quantify disease progression and treatment efficacy. Based on a limited number of studies, MRI can detect changes in the bone marrow fat distribution and fibrosis caused by the progression and treatment of MF. This work seeks quantitative measures such as proton density fat fraction, magnetization transfer and diffusion weighted imaging to investigate proportions of fat, cellularity and fibrosis in bone marrow caused by MF.

This abstract and the presentation materials are available to members only; a login is required.

Join Here