Arterial spin labeling (ASL) approaches for measuring perfusion are challenging in white matter due in part to longer blood arrival times. We implemented a cross-correlation-based processing approach on multi-delay ASL data acquired in Human Connectome Project-Aging (HCP-A) to quantify white matter arterial transit time (ATT) and used these ATT values to analytically compute white matter CBF. Using this approach, we found that white matter CBF decreases (ρ=0.39) and white matter ATT elongates (ρ=0.42) with increasing age (p<0.001). We also found that CBF and ATT values are spatially heterogeneous, with periventricular white matter exhibiting the lowest CBF and longest ATT.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords