Abstract #2361

High resolution imaging of choroid plexus blood flow with multi-delay pseudo-continuous arterial spin labeling

Xingfeng Shao¹, Chenyang Zhao¹, Matthew Borzage², Catherine Mark³, Elizabeth Joe⁴, Jonathan Russin^3,5, Charles Liu^3,4,5, Darrin Lee^3,5,6, and Danny JJ Wang^1,4

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁴Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁵USC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁶Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

In this study we developed an arterial spin labeling (ASL) sequence with high spatial/temporal resolution and utilized a post-processing denoising method to measure dynamic choroid plexus (CP) perfusion signal. Quantified CP blood flow was evaluated in heathy subjects and one normal pressure hydrocephalus (NPH) patient and compared with water exchange rate across the blood-brain barrier (BBB). Our preliminary results show that CP blood flow may be altered in NPH and has a potential relation with water exchange rate across the BBB.

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