Abstract #2362

ADC change during cardiac cycle in idiopathic normal pressure hydrocephalus before and after tap test and shunt surgery

Ryo Yagawa¹, Naoki Ohno¹, Tosiaki Miyati¹, Mitsuhito Mase², Tomoshi Osawa², Harumasa Kasai², Yuta Shibamoto², and Satoshi Kobayashi¹

¹Division of Health Sciences, Kanazawa University, Kanazawa, Japan, ²Nagoya City University Hospital, Nagoya, Japan

To assess the dynamic changes in the apparent diffusion coefficient (ADC) during the cardiac cycle (ΔADC) of the brain before and after the lumbar tap and shunt surgery for the purpose of determining changes in hydrodynamic and biomechanical properties in the brain after cerebrospinal fluid (CSF) drainage for iNPH. The frontal white matter ΔADC in iNPH decreased after the lumbar tap and shunt surgery. ΔADC analysis may provide detailed information regarding changes in the hydrodynamic and biomechanical properties through CSF drainage.

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