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Abstract #2362

ADC change during cardiac cycle in idiopathic normal pressure hydrocephalus before and after tap test and shunt surgery

Ryo Yagawa1, Naoki Ohno1, Tosiaki Miyati1, Mitsuhito Mase2, Tomoshi Osawa2, Harumasa Kasai2, Yuta Shibamoto2, and Satoshi Kobayashi1
1Division of Health Sciences, Kanazawa University, Kanazawa, Japan, 2Nagoya City University Hospital, Nagoya, Japan

To assess the dynamic changes in the apparent diffusion coefficient (ADC) during the cardiac cycle (ΔADC) of the brain before and after the lumbar tap and shunt surgery for the purpose of determining changes in hydrodynamic and biomechanical properties in the brain after cerebrospinal fluid (CSF) drainage for iNPH. The frontal white matter ΔADC in iNPH decreased after the lumbar tap and shunt surgery. ΔADC analysis may provide detailed information regarding changes in the hydrodynamic and biomechanical properties through CSF drainage.

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