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Abstract #2366

Association of Enlarged Perivascular Spaces and Sleep Disturbances in Military-related Mild Traumatic Brain Injury

Ping-Hong Yeh1, J. Kent Werner2,3, Rujirutana Srikanchana1, Kimbra Kenney1,2, Treven Pickett1,2, Grant Bonavia1,2, Gerard Riedy1,2, and John Ollinger1
1National Intrepid Center of Excellence, Bethesda, MD, United States, 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 3Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States

Sleep disturbances are common following traumatic brain injury (TBI). We sought to quantify changes in perivascular space (PVS) in combat-related mild TBI (mTBI) patients and explore the association between normalized PVS volume and sleep measures. We found mTBI patients with previous potential concussive event (PCE) (TBIPCE) had larger PVS fraction than controls. A subjective sleep measure, The Pittsburgh Sleep Quality Index (PSQI), was positively associated with PVS in TBIPCE patients, which had mean higher PSQI than those of TBI patients who had only mTBI but no PCE. This result suggests enlarged PVS may be modulated by sleep and TBI.

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