Abstract #2366

Association of Enlarged Perivascular Spaces and Sleep Disturbances in Military-related Mild Traumatic Brain Injury

Ping-Hong Yeh¹, J. Kent Werner^2,3, Rujirutana Srikanchana¹, Kimbra Kenney^1,2, Treven Pickett^1,2, Grant Bonavia^1,2, Gerard Riedy^1,2, and John Ollinger¹

¹National Intrepid Center of Excellence, Bethesda, MD, United States, ²Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ³Center for Neuroscience and Regenerative Medicine, Bethesda, MD, United States

Sleep disturbances are common following traumatic brain injury (TBI). We sought to quantify changes in perivascular space (PVS) in combat-related mild TBI (mTBI) patients and explore the association between normalized PVS volume and sleep measures. We found mTBI patients with previous potential concussive event (PCE) (TBIPCE) had larger PVS fraction than controls. A subjective sleep measure, The Pittsburgh Sleep Quality Index (PSQI), was positively associated with PVS in TBIPCE patients, which had mean higher PSQI than those of TBI patients who had only mTBI but no PCE. This result suggests enlarged PVS may be modulated by sleep and TBI.

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