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Abstract #2367

Cerebrospinal fluid water fraction increases with age in normal aging

Thanh D Nguyen1, Liangdong Zhou1, Elizabeth Sweeney1, Xiuyuan Wang1, Susan A Gauthier1, Yi Wang1, Amy Kuceyeski1, and Yi Li1
1Weill Cornell Medicine, New York, NY, United States

Perivascular spaces (PVS) play a key role in the glial-lymphatic waste clearance pathway in the brain. We applied FAST-T2 multi-component T2 relaxometry to 20 healthy volunteers between 30 and 60 years old and found a significant relationship between CSF water fraction and age in the frontal and temporal cortex, while the brain tissue water content measured by T1 relaxation time remains stable over time. Our results suggest that CSF fraction may be a useful quantitative biomarker of PVS dilation in normal aging.

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