Abstract #2368

Diffusion and perfusion characteristics of brain white matter prone to hyperintensities: a four-year longitudinal study

Shruti Agarwal¹, Jay J. Pillai^1,2, and Hanzhang Lu^3,4

¹Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

White matter hyperintensities (WMH) are white matter brain lesions found as areas of increased signals on T2-weighted and FLAIR MRI scans. A large majority of elderly individuals have a certain degree of WMH which may be associated with cognitive decline, decline in physical function and a higher risk of stroke and death. To date, neurobiological mechanisms underlying and predictive of WMH is not fully characterized. In this study, we aim to use a longitudinal design to elucidate hallmarks of brain tissue at baseline that will predict a “conversion” from normal-appearing WM (NAWM) to WMH over a four-year period.

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