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Abstract #2369

Callosal Angle Biomarker for Normal Pressure Hydrocephalus Calculated for 4,980 T1-Weighted MR Exams

Alexander Saunders1,2, Stefan Bluml1,2, Kevin S King3, and Matthew Borzage2,4
1Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 2Rudi Schulte Research Insitute, Santa Barbara, CA, United States, 3Barrow Neurological Institute, Phenoix, AZ, United States, 4Children's Hospital Los Angeles, Los Angeles, CA, United States

Normal pressure hydrocephalus is a treatable dementia often misdiagnosed as Alzheimer’s Disease. Callosal angle measurement distinguish normal pressure hydrocephalus from other dementias but measurements are time-consuming and subjective. Therefore, we developed an algorithm for automatic callosal angle measurement and calculated callosal angles for 4,980 T1-weighted MRIs from databases of patients with purportedly healthy aging brains or Alzheimer’s. Based on the published guidelines, 1.8-4.3% of exams in these databases indicate patients likely have normal pressure hydrocephalus and thus a treatable form of dementia. Our automatic measurement of the callosal angle biomarker can rapidly and objectively screen patients for normal pressure hydrocephalus.

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