Abstract #2369

Callosal Angle Biomarker for Normal Pressure Hydrocephalus Calculated for 4,980 T1-Weighted MR Exams

Alexander Saunders^1,2, Stefan Bluml^1,2, Kevin S King³, and Matthew Borzage^2,4

¹Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ²Rudi Schulte Research Insitute, Santa Barbara, CA, United States, ³Barrow Neurological Institute, Phenoix, AZ, United States, ⁴Children's Hospital Los Angeles, Los Angeles, CA, United States

Normal pressure hydrocephalus is a treatable dementia often misdiagnosed as Alzheimer’s Disease. Callosal angle measurement distinguish normal pressure hydrocephalus from other dementias but measurements are time-consuming and subjective. Therefore, we developed an algorithm for automatic callosal angle measurement and calculated callosal angles for 4,980 T1-weighted MRIs from databases of patients with purportedly healthy aging brains or Alzheimer’s. Based on the published guidelines, 1.8-4.3% of exams in these databases indicate patients likely have normal pressure hydrocephalus and thus a treatable form of dementia. Our automatic measurement of the callosal angle biomarker can rapidly and objectively screen patients for normal pressure hydrocephalus.

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