We investigated white matter (WM), cerebral blood flow (CBF) and free water content (FW) in the penumbra region surrounding white matter hyperintensities (WMH) in elderly participants. The tissue surrounding WMH clusters were defined as four 1mm concentric layers and compared to WM and WMHs. The findings of this study reveal that WMHs and adjacent layers have lower CBF than healthy WM and CBF increases from lower layers to higher layers. The opposite associations were found with FW.
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