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Abstract #2371

Reduced cerebrovascular reactivity and cerebral blood flow in White Matter Hyperintensities (WMHs)

Chenyang Li1,2, Marco Muccio1, Dengrong Jiang3, Peiying Liu3, Jiangyang Zhang1, Arjun Masurkar4, Thomas Wisniewski4, Hanzhang Lu3, and Yulin Ge1
1Department of Radiology, Center for Biomedical Imaging, NYU Grossman School of Medicine, New York, NY, United States, 2Vilcek Institute of Graduate Biomedical Sciences, NYU Grossman School of Medicine, New York, NY, United States, 3Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 4Department of Neurology, NYU Grossman School of Medicine, New York City, NY, United States

Understanding of in vivo vascular pathophysiology in white matter hyperintensities (WMHs) is still incomplete. Compared to grey matter, white matter is considerably less vascularized and tends to have lower blood flow. Therefore, sensitive detection and accurate estimation for white matter hemodynamics is crucial for early prevention and mechanistic understanding of WMHs pathogenesis and progression. In this study, we implemented advanced neurovascular MRI techniques to evaluate the white matter hemodynamics including cerebral blood flow and cerebrovascular reactivity in patients with varying degrees of WMHs.

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