Abstract #2372

Decoupling between global brain activity and cerebrospinal fluid flow is associated with Alzheimer's disease pathologies

Feng Han¹, Jing Chen¹, Aaron Belkin-Rosen¹, Yameng Gu¹, Liying Luo^2,3, Orfeu M Buxton⁴, and Xiao Liu^1,5

¹Department of Biomedical Engineering, The Pennsylvania State University, State College, PA, United States, ²Department of Sociology & Criminology, The Pennsylvania State University, State College, PA, United States, ³Population Research Institute, The Pennsylvania State University, State College, PA, United States, ⁴Department of Biobehavioral Health, The Pennsylvania State University, State College, PA, United States, ⁵Institute for Computational and Data Sciences, The Pennsylvania State University, State College, PA, United States

Glymphatic system responsible for brain waste clearance may play an important role in the development of Alzheimer's disease (AD). However, this possibility has not been sufficiently studied in AD patients due to a lack of non-invasive tools for gauging glymphatic function. Low-frequency (<0.1 Hz) fMRI signals have been recently linked to glymphatic function, and its global signal was found to be coupled with CSF flow known to be essential for glymphatic clearance. Here, we used the coupling of global BOLD signal and CSF to quantify glymphatic function and found this BOLD-CSF coupling metric is significantly correlated with various AD pathologies.

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