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Abstract #2373

Cerebrovascular Reactivity and Cerebral Blood Flow across lifespan in females

Safa Sanami1, Brittany Intzandt2,3,4, Fatemeh Razavipour1, Julia Huck1, Richard D Hoge5, Louis Bherer3,4,6,7, and Claudine J Gauthier1,4,6
1Physics, Concordia University, Montreal, QC, Canada, 2INDI, Concordia University, Montreal, QC, Canada, 3Centre de Recherche de l'Institut Universitaire de Geriatrie, Montreal, QC, Canada, 4Centre de Recherche, l'Institut de Cardiologie de Montréal, Montreal, QC, Canada, 5Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 6PERFORM Centre, Concordia University, Montreal, QC, Canada, 7Départment de Médicine, Université de Montréal, Montreal, QC, Canada

Aging is associated with cerebrovascular impairments in males and females, yet this impairment develops nearly one decade later in females. Although cerebral blood flow (CBF) is consistently reported as higher in females, results on cerebrovascular reactivity (CVR) have not been uniform in studies comparing females to males. Here, given that much less is known about cerebrovascular changes in females than males, we examined CBF and CVR during aging in healthy females only. Our results revealed that both CBF and CVR decline across the lifespan in females. Future work should include hormone levels, arterial stiffness, other vascular risk factors, and males.

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