Aging is associated with cerebrovascular impairments in males and females, yet this impairment develops nearly one decade later in females. Although cerebral blood flow (CBF) is consistently reported as higher in females, results on cerebrovascular reactivity (CVR) have not been uniform in studies comparing females to males. Here, given that much less is known about cerebrovascular changes in females than males, we examined CBF and CVR during aging in healthy females only. Our results revealed that both CBF and CVR decline across the lifespan in females. Future work should include hormone levels, arterial stiffness, other vascular risk factors, and males.