Abstract #2373

Cerebrovascular Reactivity and Cerebral Blood Flow across lifespan in females

Safa Sanami¹, Brittany Intzandt^2,3,4, Fatemeh Razavipour¹, Julia Huck¹, Richard D Hoge⁵, Louis Bherer^3,4,6,7, and Claudine J Gauthier^1,4,6

¹Physics, Concordia University, Montreal, QC, Canada, ²INDI, Concordia University, Montreal, QC, Canada, ³Centre de Recherche de l'Institut Universitaire de Geriatrie, Montreal, QC, Canada, ⁴Centre de Recherche, l'Institut de Cardiologie de Montréal, Montreal, QC, Canada, ⁵Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ⁶PERFORM Centre, Concordia University, Montreal, QC, Canada, ⁷Départment de Médicine, Université de Montréal, Montreal, QC, Canada

Aging is associated with cerebrovascular impairments in males and females, yet this impairment develops nearly one decade later in females. Although cerebral blood flow (CBF) is consistently reported as higher in females, results on cerebrovascular reactivity (CVR) have not been uniform in studies comparing females to males. Here, given that much less is known about cerebrovascular changes in females than males, we examined CBF and CVR during aging in healthy females only. Our results revealed that both CBF and CVR decline across the lifespan in females. Future work should include hormone levels, arterial stiffness, other vascular risk factors, and males.

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