Abstract #2374

Changes of Choroid Plexus Volume in Alzheimer’s Patients

Li Zhao¹, Xue Feng², Yueqin Hu³, Dan Wu¹, Craig H. Meyer², and David C. Alsop⁴

¹College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ³Psychology, Beijing Normal University, Beijing, China, ⁴Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Choroid plexus volume was investigated using a deep learning segmentation method, which has demonstrated higher accuracy than the previous atlas-based method. Therefore, a higher sensitivity was expected with the new method. MR images of 733 subjects were selected retrospectively, including healthy volunteers, MCI and AD patients. The results show that 1) the choroid plexus volume increases with age; 2) is smaller in the female subjects; and 3) is larger in the MCI and AD patients compared to the healthy volunteers. Our preliminary results suggest that the choroid plexus volume changes with brain aging.

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