Choroid plexus volume was investigated using a deep learning segmentation method, which has demonstrated higher accuracy than the previous atlas-based method. Therefore, a higher sensitivity was expected with the new method. MR images of 733 subjects were selected retrospectively, including healthy volunteers, MCI and AD patients. The results show that 1) the choroid plexus volume increases with age; 2) is smaller in the female subjects; and 3) is larger in the MCI and AD patients compared to the healthy volunteers. Our preliminary results suggest that the choroid plexus volume changes with brain aging.