The effect of white matter hyperintensities (WMHs) on 50 major WM tractometries was investigated. Elevated WMHs load on white matter tract was associated with lower apparent fiber density (AFD) on tractometery, showing the co-localization of WMH with AFD change. Reduced AFD is associated with lower connectivity of the WM tract. Differences in these metrics between lower WMH and higher WMH groups, and between lower WMH and MCI groups are significant. Moreover, AFD is lower in individuals with MCI, supporting a role of white matter microstructure in cognitive decline.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords