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Abstract #2389

Biochemical Composition of the Cerebrospinal Fluid: Probing by MRI

Khin Khin Tha1,2, Yuta Urushibata3, Hiroyuki Hamaguchi2, and Hideki Hyodoh4
1Global Center for Biomedical Science and Engineering, Hokkaido University Faculty School of Medicine, Sapporo, Japan, 2Department of Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, 3Siemens Healthcare K.K., Tokyo, Japan, 4Department of Forensic Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan

This prospective study aimed to evaluate if CEST MRI can detect the biochemical composition of CSF. Fifty-two cadaveric CSF samples were tested for any correlation between the compounds detected by CEST MRI and the CSF biochemical analysis reports. The normalized area for intermediate exchanging amines showed a moderate positive correlation with protein concentration (r= 0.436, P= 0.001), a weak positive correlation with specific gravity (r=0.369, P=0.007), and a weak negative correlation with pH (r= -0.290, P= 0.037). The normalized area for intermediate exchanging amines may be sensitive to detect a change in CSF proteins.

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