This prospective study aimed to evaluate if CEST MRI can detect the biochemical composition of CSF. Fifty-two cadaveric CSF samples were tested for any correlation between the compounds detected by CEST MRI and the CSF biochemical analysis reports. The normalized area for intermediate exchanging amines showed a moderate positive correlation with protein concentration (r= 0.436, P= 0.001), a weak positive correlation with specific gravity (r=0.369, P=0.007), and a weak negative correlation with pH (r= -0.290, P= 0.037). The normalized area for intermediate exchanging amines may be sensitive to detect a change in CSF proteins.
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