In this study, we optimise the variable flip angle acquisition protocol for GRE-based myelin water imaging using MCR model. We show numerically and via in vivo imaging that MCR-MWI can be performed with as few as 3 flip angles and still be able to achieve similar measurement performance as with 7 flip angles. We also conduct an analysis to investigate the usefulness of an image denoising method to improve MWI. Preliminary results suggest that MCR-MWI is very robust to noise and higher resolution data is needed to have a better insight.
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