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Abstract #2393

Evaluation of different b-value sampling strategies in cerebral IVIM: application to interstitial fluid

Gerhard Drenthen1, Jacobus Jansen1, Paulien Voorter1, Joost de Jong1, and Walter Backes1
1Maastricht University Medical Center, Maastricht, Netherlands

Recently, it was shown that besides the parenchymal diffusion and microvascular perfusion an additional, intermediate, component can be observed in the IVIM signal. The fraction of this intermediate diffusion ($$$f_{int}$$$) is suggested to be related to interstitial fluid in the perivascular spaces (PVS). In this study we examine several b-value sampling strategies for measuring the ($$$f_{int}$$$) using simulated IVIM data. When a large intermediate diffusion component is present in the IVIM signal (eg. white matter hyperintensities), b-value sampling strategies specifically aimed to quantify this component can provide better estimates of $$$f_{int}$$$ compared to linear or logarithmic spaced b-values.

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