Recently, it was shown that besides the parenchymal diffusion and microvascular perfusion an additional, intermediate, component can be observed in the IVIM signal. The fraction of this intermediate diffusion ($$$f_{int}$$$) is suggested to be related to interstitial fluid in the perivascular spaces (PVS). In this study we examine several b-value sampling strategies for measuring the ($$$f_{int}$$$) using simulated IVIM data. When a large intermediate diffusion component is present in the IVIM signal (eg. white matter hyperintensities), b-value sampling strategies specifically aimed to quantify this component can provide better estimates of $$$f_{int}$$$ compared to linear or logarithmic spaced b-values.
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