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Abstract #2395

Isotropic water content mapping employing super-resolution reconstruction with acquisition in three orthogonal orientations

Dennis Thomas1,2, Ana-Maria Oros-Peusquens1, Dirk Poot3, and N. Jon Shah1,4,5,6
1Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich, Jülich, Germany, 2RWTH Aachen University, Aachen, Germany, 3Department of Radiology and Nuclear medicine, Erasmus Medical Center, Rotterdam, Netherlands, 4Department of Neurology, RWTH Aachen University, Aachen, Germany, 5Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Jülich, Germany, 6JARA - BRAIN - Translational Medicine, Aachen, Germany

Tissue water content is highly regulated in the healthy brain, and even small changes are indicative of pathology. It also constitutes an important source of anatomic MRI contrast. However, this contrast remains insufficiently explored, partly due to lengthy measurement times and relatively low resolution. Super-resolution reconstruction techniques offer a trade-off between resolution, scan time and SNR.The goal of this work was to develop a technique to achieve high resolution, whole-brain water content maps by employing super-resolution reconstruction techniques. Results from the developed technique were evaluated with a carrageenan phantom and whole-brain water content maps acquired from a healthy volunteer.

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