Multi-modal magnetic resonance (MR) image registration is essential in the clinic to achieve accurate imaging-based disease diagnosis and treatment planning. Although the existing registration methods have achieved good performance and attracted widespread attention, the image details may be lost after registration. In this study, we propose a multi-modal MR image registration with topology-preserving dual consistency constraint, which achieves the best registration performance with a Dice score of 0.813 in identifying stroke lesions.
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