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Abstract #2455

Evaluation of quantitative MRI parameters reproducibility across a major scanner upgrade: spinal cord diffusion weighted (DW) imaging

Ratthaporn Boonsuth1, Marco Battiston1, Francesco Grussu1,2, Marios Yiannakas1, Torben Schneider3, Rebecca Samson1, Ferran Prados1,4,5, and Claudia A. M. Gandini Wheeler-Kingshott1,6,7
1NMR research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, United Kingdom, 2Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 3Philips Healthcare, Guildford, Surrey, United Kingdom, 4Centre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 5E-Heath Centre, Universitat Oberta de Catalunya, Barcelona, Spain, 6Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 7Department of Brain Connectivity Centre Research Department, IRCCS Mondino Foundation, Pavia, Italy

Major MRI scanner upgrades can potentially introduce systematic changes in quantitative MRI metrics and affect reliability and reproducibility of quantitative parameters. Advanced diffusion weighted (DW) imaging methods are a powerful diagnostic and research tool in the brain and in spinal cord, but it is unclear to what extent DW-derived metrics can be affected by upgrades. Here we assess the effect of scanner upgrades on state-of-the-art spinal cord DW techniques. We found that diffusion matrices such as FA, MD and MK remain stable following a major upgrade when measured in the whole spinal cord, white matter, and grey matter areas.

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