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Abstract #2456

High-resolution microstructural imaging in the human hippocampus with b-tensor encoding and zoomed imaging

Jiyoon Yoo1, Leevi Kerkelä1, Patrick W. Hales1, Kiran K. Seunarine1, Iulius Dragonu2, Enrico Kaden1, and Christopher A. Clark1
1UCL Great Ormond Street Institute of Child Health, London, United Kingdom, 2Siemens Healthcare Ltd, Frimley, United Kingdom

In this work, our protocol leverages the most recent advances in the b-tensor diffusion encoding, and also uses a zoomed imaging technique, to specifically scan the hippocampus. Our sequence is able to acquire high-resolution images which enable direct delineation of hippocampal structures and allows estimation of advanced diffusion metrics, as well as parameters that can be measured from a standard multi-shell diffusion data set. Therefore, our acquisition can be used as an all-in-one sequence for microstructural imaging of the hippocampus. We also defined a subsampled acquisition protocol that is feasible for a clinical setting.

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