Abstract #2465

The diffusion time dependence of MAP-MRI parameters in the human brain

Alexandru V Avram^1,2, Qiyuan Tian³, Qiuyun Fan³, Susie Y Huang^3,4, and Peter J Basser¹

¹Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ²Center for Neuroscience and Regenerative Medicine, The Henry Jackson Foundation, Bethesda, MD, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ⁴Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

We acquire mean apparent propagator (MAP) MRI data in the human brain using different diffusion times. We characterize the diffusion-time dependence of propagator metrics in vivo and compute the statistical distance between co-registered propagators measured with short and long diffusion times. We derive time-scaling parameters that can assess anomalous diffusion in disordered, fractal-like tissue environments. Preliminary results suggest that the diffusion-time dependence of in vivo MRI signals is strongly modulated by restrictions and hindrances that occur over a range of length scales and could provide new contrasts to quantify structural and architectural differences in healthy and diseased tissues.

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