To date, limited attention has been paid to diffusion-weighted (DW) MRI signal modelling of the liver, where new imaging methods are needed to tackle diseases such as cancer. We report on Monte Carlo (MC) simulations run in synthetic hepatic cells to inform the developing of new model-based methods for liver application. We specifically investigate the question: “can cell size and diffusivity be estimated from signal cumulants at fixed diffusion time and realistic SNR?”, and find that the task is feasible for clinical diffusion times and b=0 SNR as low as 20, provided that both apparent diffusivity and kurtosis are considered.
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