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Abstract #2468

Single-shot measurement of sub-millisecond, time-dependent diffusion using optimized, unequal pulse spacings in a static field gradient

Teddy Xuke Cai1,2, Nathan Hu Williamson1,3, Velencia Witherspoon1, Rea Ravin1,4, and Peter Basser1
1Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States, 2Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 3National Institute of General Medical Sciences, Bethesda, MD, United States, 4Celoptics, Inc., Rockville, MD, United States

Time-dependent diffusion contains rich information about the tissue microstructure. Conventional methods to measure the time-varying diffusivity probe a single timescale per acquisition, limiting time resolution. Furthermore, access to sub-millisecond timescales is limited by the pulsed gradient hardware. An alternative method is presented here. We extend the static field gradient, Carr-Purcell-Meiboom-Gill cycle by incrementing the $$$\pi$$$-pulse spacings to isolate the on-resonance signal. The resulting spin echo train probes a range of short timescales (50 – 500 microseconds) in one shot and enables a 1-minute time-dependent diffusivity measurement. Proof-of-principle simulations and experimental results on pure liquids and yeast are presented.

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