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Abstract #2497

Signal-to-noise-ratio gain and in vivo application of a 13C cryo-coil for hyperpolarized MRSI

Luca Nagel1, Geoffrey J. Topping1, and Franz Schilling1
1Department of Nuclear Medicine, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Munich, Germany

Cryogenically cooled transmit/receive radiofrequency coils (cryocoils) improve the signal-to-noise ratio (SNR) compared to conventional RF coils by minimizing thermal coil noise. The SNR of a cryoprobe, a surface coil at room temperature and a volume coil was assessed using chemical shift imaging of a 13C-urea phantom. Using the cryocoil an SNR improvement up to a factor of 10 compared to conventional coils was observed. In addition, a proof-of-concept in vivo experiment using the 13C-cryocoil for detection of the metabolic turnover of hyperpolarized 13C-pyruvate was successfully performed.

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