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Abstract #2517

Comparison of pharmacokinetic models for assessing murine renal function by DCE-MRI

Soham Mukherjee1, Mahon L Maguire1, Jack Sharkey1, Sourav Bhaduri1, Patricia Murray2, Rachel Bearon3, Bettina Wilm2, and Harish Poptani1
1Centre for Preclinical Imaging, University of Liverpool, Liverpool, United Kingdom, 2Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, United Kingdom, 3Department of Mathematical Sciences, University of Liverpool, Liverpool, United Kingdom

Quantitative analysis of kidney function is essential part of monitoring disease progression. The most common parameter of evaluating kidney functioning is by measurement of glomerular filtration rate. Here, we describe that dynamic contrast enhanced magnetic resonance imaging can be used to determine the permeability parameter Ktrans, which can be used to assess renal activity. We used three different pharmacokinetic models and arterial input functions to get the Ktrans value. It was seen that the raw arterial input function used along with shutter speed model has strong correlation with findings obtained from transcutaneous GFR measurement device.

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