Due to non-Gaussian nature of water diffusion in tissues, the measured diffusion-related parameters depend on b-values and diffusion time. In fact, our study shows that the apparent diffusion coefficient (ADC) and IVIM-related diffusion coefficient D obtained in the human kidney slightly increase with the diffusion time in the range between 20 ms and 45 ms, as opposed to ADC and D of skeletal muscle. Among all investigated diffusion parameters, the IVIM-based pseudodiffusion coefficient D* exhibits the strongest dependence on diffusion time and could potentially provide valuable information regarding the blood vessels and urine flow in the kidney.
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