Meeting Banner
Abstract #2526

Detection of fibrosis in patients with moderate renal impairment with multiparametric MRI

Pete Thelwall1,2, Jehill Parikh1, Benjamin Pippard1, Caroline Wroe3, Rob Janiczek4, Steven Sourbron5, and Neil Sheerin1
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Centre for In Vivo Imaging, Newcastle University, Newcastle upon Tyne, United Kingdom, 3South Tees Hospitals NHS Foundation Trust, Middlesborough, United Kingdom, 4GlaxoSmithKline, Philadelphia, PA, United States, 5University of Sheffield, Sheffield, United Kingdom

A multiparametric renal MRI scan protocol was employed to characterise the impact of renal fibrosis on tissue relaxation properties. The study recruited patients with moderate renal dysfunction (CKD stage 3, eGFR between 30 and 60 ml/min/1.73 m2) with biopsy-proven fibrosis and age-matched healthy volunteers. Statistically significant differences in kidney cortical native T1 and T2 were observed between patients and controls, ascribed to tissue microstructural changes associated with the mild fibrosis observed in the patient group.

This abstract and the presentation materials are available to members only; a login is required.

Join Here