Abstract #2553

In Vivo Assessment Of Metabolic Abnormality In Alport Syndrome Using Hyperpolarized [1-13C]Pyruvate MR Spectroscopic Imaging

Nguyen Trong Nguyen¹, Ilwoo Park^2,3, Ngoc Luu Do², Tien Anh Nguyen², Sang Heon Suh ⁴, Eun Hui Bae⁴, and Sang Soo Shin²

¹Department of Biomedical Science, Chonnam National University, Gwangju, Korea, Republic of, ²Department of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of, ³Department of Artificial Intelligence Convergence, Chonnam National University, Gwangju, Korea, Republic of, ⁴Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea, Republic of

Alport Syndrome (AS) is an inherited kidney disease with progressive kidney failure. We investigate the potential of hyperpolarized 13C MRI to be used as an non-invasive technique for detecting early abnormal changes in renal metabolism. Hyperpolarized [1-13C]pyruvate imaging was applied to AS and wild-type mice at 4- and 7-week-old. Normalized Lactate in AS model was significantly lower at 7-week compared to 4-week. This abnormal renal metabolism in AS mice was consistent with PEPCK analysis, which showed increased expression level as the disease progressed. We demonstrated the feasibility of this technique for assessing early renal function in mouse model of AS.

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