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Abstract #2553

In Vivo Assessment Of Metabolic Abnormality In Alport Syndrome Using Hyperpolarized [1-13C]Pyruvate MR Spectroscopic Imaging

Nguyen Trong Nguyen1, Ilwoo Park2,3, Ngoc Luu Do2, Tien Anh Nguyen2, Sang Heon Suh 4, Eun Hui Bae4, and Sang Soo Shin2
1Department of Biomedical Science, Chonnam National University, Gwangju, Korea, Republic of, 2Department of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of, 3Department of Artificial Intelligence Convergence, Chonnam National University, Gwangju, Korea, Republic of, 4Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea, Republic of

Alport Syndrome (AS) is an inherited kidney disease with progressive kidney failure. We investigate the potential of hyperpolarized 13C MRI to be used as an non-invasive technique for detecting early abnormal changes in renal metabolism. Hyperpolarized [1-13C]pyruvate imaging was applied to AS and wild-type mice at 4- and 7-week-old. Normalized Lactate in AS model was significantly lower at 7-week compared to 4-week. This abnormal renal metabolism in AS mice was consistent with PEPCK analysis, which showed increased expression level as the disease progressed. We demonstrated the feasibility of this technique for assessing early renal function in mouse model of AS.

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