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Abstract #2554

Intravoxel Incoherent Motion Diffusion-weighted MRI in Kidneys of Acute Leukemia and Its Clinical Significance: A Pilot Study

Jianting Li1, Jinliang Niu1, and Rong Zheng2
1The second hospital of Shanxi medical university, Taiyuan, China, 2The first hospital of Shanxi medical university, Taiyuan, China

36% of high-grade hematological malignancies patients suffer acute kidney injury (KI), including leukemia. Autopsy data suggested that kidney involvement represent a significant proportion of patients with acute leukemia (AL), ranging from 50% to 100%. Therefore, it is crucial to diagnose KI early and accurately. Clinical symptoms and renal biopsy are limited in diagnosing KI. Intravoxel incoherent motion MRI (IVIM) can reflect the diffusion and perfusion of kindeys. It is reported that some parameters are sensitive to renal pathological processes of focal and diffuse lesions. Thus, IVIM may offer an opportunity to identify early changes in renal function in AL.

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