36% of high-grade hematological malignancies patients suffer acute kidney injury (KI), including leukemia. Autopsy data suggested that kidney involvement represent a significant proportion of patients with acute leukemia (AL), ranging from 50% to 100%. Therefore, it is crucial to diagnose KI early and accurately. Clinical symptoms and renal biopsy are limited in diagnosing KI. Intravoxel incoherent motion MRI (IVIM) can reflect the diffusion and perfusion of kindeys. It is reported that some parameters are sensitive to renal pathological processes of focal and diffuse lesions. Thus, IVIM may offer an opportunity to identify early changes in renal function in AL.