Neoadjuvant chemotherapy(NAC) becomes the standard treatment for muscular invasive bladder cancer (MIBC), some patients do not respond to NAC. So the purpose of this study was to evaluate the potential of diffusion-weighted (DW) magnetic resonance imaging (MRI) with an ADC map in the prediction of response to NAC in patients with MIBC. In our study, all the sixty-two MIBC patients have underwent DW-MRI before and after NAC. After NAC, patients were classified into responders or non-responders by the Response Evaluation Criteria in Solid Tumors. However, there was no statistically significant difference in ADC between responders and non-responders before NAC.