Abstract #2556

Longitudinal brain network changes in the GAERS rat model of absence epilepsy

Leo Hebbelmann¹, Lydia Wachsmuth¹, Henriette Lambers¹, Cornelius Faber¹, Annika Lüttjohann², and Thomas Budde²

¹Translational Research Imaging Center Clinic for Radiology, University of Münster, Münster, Germany, ²Physiology I, University of Münster, Münster, Germany

Resting-state fMRI under Isoflurane was performed to characterize brain networks in 4 and 8 month old Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and in non-epileptic controls (NEC). Graph theoretical analysis identified major differences in intra-thalamic connectivity with age and compared to NEC, indicating that thalamus is strongly involved and probably modulated by frequently occurring seizures. In contrast, in NEC, brain networks did not change considerably in the age range studied.

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