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Abstract #2557

Anatomical and diffusion tensor MRI reveal microstructural effects of tau pathology in the inter-cerebellar fibres of the hTau.P301S mouse model

Ernest Eng1, Raimo Salo1, Heikki Tanila1, Mikko Kettunen1, and Olli Gröhn1
1A.I. Virtanen Institute for Molecular Sciences, Finland, Kuopio, Finland

The hTau.P301S-Tg mouse is an excellent model to study human tauopathy but knowledge about how tau affects the microstructure remains limited. We therefore performed anatomical and diffusion MRI to uncover structural regions likely affected by tauopathy and to characterise its progression. No initial morphometrical differences were found at 2.5 months of age. However, at 5 months, hTau.P301S mice exhibited local volumetric cerebellar changes and significantly lower FA and AD values, but higher RD values in inter-cerebellar fibres. Our data indicates that tauopathy results in structural and microstructural changes in the inter-cerebellar fibres, and possibly associates with the model’s motor declines.

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