The hTau.P301S-Tg mouse is an excellent model to study human tauopathy but knowledge about how tau affects the microstructure remains limited. We therefore performed anatomical and diffusion MRI to uncover structural regions likely affected by tauopathy and to characterise its progression. No initial morphometrical differences were found at 2.5 months of age. However, at 5 months, hTau.P301S mice exhibited local volumetric cerebellar changes and significantly lower FA and AD values, but higher RD values in inter-cerebellar fibres. Our data indicates that tauopathy results in structural and microstructural changes in the inter-cerebellar fibres, and possibly associates with the model’s motor declines.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords