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Abstract #2561

Brain connectivity impairments revealed by DTI and resting-state fMRI in a mouse model of Huntington’s disease

Jean-Baptiste Pérot1, Marina Célestine1, Miriam Riquelme-Pérez1, Carole Escartin1, Marc Dhenain1, Emmanuel Brouillet1, and Julien Flament1
1Université Paris-Saclay, Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Molecular Imaging Research Center (MIRCen), Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France

Huntington’s Disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats on the exon 1 of the HTT gene. Atrophy of the striatum is currently the main biomarker of the disease’s progression, but there is a need to find earlier and more functional biomarkers. Here, we evaluated Diffusion Tensor Imaging (DTI) and resting-state fMRI (rs-fMRI) as biomarkers in heterozygous zQ175 mice, a model mimicking the presymptomatic phase of HD. Our protocol allowed detection of vulnerable brain networks that would be of great interest for better understanding of the pathogenesis in clinical HD.

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