Abstract #2562

High Resolution DTI Tractographic Analysis in a Mouse Model of Pruritis

Talaignair N Venkatraman¹, Ouyang Chen², Allen W Song³, Ru-Rong Ji², and Christopher D Lascola¹

¹Radiology, Duke University Medical Center, Durham, NC, United States, ²Neurobiology, Duke University Medical Center, Durham, NC, United States, ³BIAC, Duke University Medical Center, Durham, NC, United States

A high resolution tractographic ROI analysis was carried out on ex vivo brain in mice with cutaneous T-cell lymphoma (CTCL), a mouse model of chronic pruritis. Our results show statistically significant differences between CTCL and control mice in DTI markers of fiber tract integrity and fiber number primarily involving the thalamus and hippocampus.

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