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Abstract #2563

Alteration of basal ganglia thalamo-cortical loop in hemiparkinsonian mouse model

Tomokazu Tsurugizawa1, Yuki Nakamura2,3,4, Yukari Nakamura2,3,4, Assunta Pelosi2,3,4, Boucif Djemai5, Clement Debacker6, Jean-Antoine Girault2,3,4, and Denis Herve2,4,7
1Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 2Inserm UMR-S 1270, Paris, France, 3Sciences and Technology Faculty, Sorbonne Universite, Paris, France, 4Institut du Fer à Moulin, Paris, France, 5NeuroSpin/CEA-Saclay, Gif-sur-Yvette, France, 6Inserm, UMR1266, Paris, France, 7Sorbonne Universite, Paris, France

Despite a few studies, our knowledge of functional connectivity in the basal ganglia-thalamo-cortical loop remains incomplete in Parkinson’s disease mouse model. Here, we investigated alterations of functional connectivity and white matter structure in a hemi-parkinsonian mouse model. We found that the fractional anisotropy significantly decreased in the lesioned side in the subthalamic nucleus, such as medio-dorsal nucleus and centromedian nucleus of thalamus. The functional connectivity in the ipsilateral thalamic nuclei was also decreased in hemiparkinsonian mice. These results indicate that ipsilateral thalamic nuclei are key regions for functional and structural alterations in basal ganglia-thalamo-cortical loop in hemiparkinsonian mice.

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