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Abstract #2564

In vivo Fixel-Based Analysis of diffusion MRI in manifested Huntington’s disease in the zQ175 HD model

Nicholas Vidas-Guscic1, Johan Van Audekerke1, Ben Jeurissen2, Jasmien Orije1, Tamara Vasilkovska1, Dorian Pustina3, Haiying Tang3, Roger Cachope3, Longbin Liu3, Mette Skinbjerg3, Celia Dominguez3, Ignacio Munoz-Sanjuan3, Annemie Van der Linden1, and Marleen Verhoye1
1Bio-Imaging Lab, university of Antwerp, Antwerp, Belgium, 2Vision Lab, university of Antwerp, Antwerp, Belgium, 3CHDI foundation, Princeton, NJ, United States

Huntington’s disease (HD) is a debilitating neurodegenerative disease that affects the motor and cognitive abilities of patients. Diffusion-weighted imaging is often used in clinical evaluation of neurodegenerative disorders and recently a fixel-based analysis method was developed to analyse diffusion data. We implemented a multi-shell diffusion weighted acquisition and analysis in the zQ175 HD model. The results of the whole-brain and region-based diffusion tensor, diffusion kurtosis and fixel-based analysis indicate the presence of micro- and macrostructural differences in the zQ175 HD model in overall white matter fibers that can be attributed to significant changes in many fiber populations throughout the brain.

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