Abstract #2564

In vivo Fixel-Based Analysis of diffusion MRI in manifested Huntington’s disease in the zQ175 HD model

Nicholas Vidas-Guscic¹, Johan Van Audekerke¹, Ben Jeurissen², Jasmien Orije¹, Tamara Vasilkovska¹, Dorian Pustina³, Haiying Tang³, Roger Cachope³, Longbin Liu³, Mette Skinbjerg³, Celia Dominguez³, Ignacio Munoz-Sanjuan³, Annemie Van der Linden¹, and Marleen Verhoye¹

¹Bio-Imaging Lab, university of Antwerp, Antwerp, Belgium, ²Vision Lab, university of Antwerp, Antwerp, Belgium, ³CHDI foundation, Princeton, NJ, United States

Huntington’s disease (HD) is a debilitating neurodegenerative disease that affects the motor and cognitive abilities of patients. Diffusion-weighted imaging is often used in clinical evaluation of neurodegenerative disorders and recently a fixel-based analysis method was developed to analyse diffusion data. We implemented a multi-shell diffusion weighted acquisition and analysis in the zQ175 HD model. The results of the whole-brain and region-based diffusion tensor, diffusion kurtosis and fixel-based analysis indicate the presence of micro- and macrostructural differences in the zQ175 HD model in overall white matter fibers that can be attributed to significant changes in many fiber populations throughout the brain.

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