Huntington’s disease (HD) is a debilitating neurodegenerative disease that affects the motor and cognitive abilities of patients. Diffusion-weighted imaging is often used in clinical evaluation of neurodegenerative disorders and recently a fixel-based analysis method was developed to analyse diffusion data. We implemented a multi-shell diffusion weighted acquisition and analysis in the zQ175 HD model. The results of the whole-brain and region-based diffusion tensor, diffusion kurtosis and fixel-based analysis indicate the presence of micro- and macrostructural differences in the zQ175 HD model in overall white matter fibers that can be attributed to significant changes in many fiber populations throughout the brain.
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