Abstract #2565

Reproducibility evaluation on resolving complex fiber orientations using diffusion spectrum imaging at 3T and 7T

Nan-Hao Chen^1,2, Kuan-Hung Cho², Yi-Ping Chao^3,4, Sheng-Min Huang², Norihiro Sadato⁵, Li-Wei Kuo^2,6, and Masaki Fukunaga⁵

¹Biomedical engineering and Environmental sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, ³Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan, ⁴Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, ⁵Division of Cerebral Integration, Department of System Neuroscience, National Institute for Physiological Sciences, Okazaki, Japan, ⁶Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan

Diffusion spectrum imaging (DSI) is a model-free diffusion MRI technique capable of resolving complex fiber orientations. The capability of DSI at different field strengths and spatial resolutions remains unexplored. This study aimed to investigate the reproducibility of DSI quantified by orientational similarity and deviation angle at 3T and 7T. Our results show that DSI reproducibility at 3T and 7T for single-fiber group are comparable, whereas DSI at 7T could provide relatively better reproducibility than that at 3T for crossing-fiber group. The comparison of spatial resolutions for crossing-fiber group suggests that partial volume effect may be less dominant than signal-to-noise ratio.

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