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Abstract #2566

High-Resolution, Whole-Brain T1 and T2 Mapping of Monkey Using 3D Magnetic Resonance Fingerprinting at 9.4 T

Yuning Gu1, Lulu Wang2, Hongyi Yang2, Yun Wu2, Yong Chen3, Kai Zhong2, and Xin Yu1,3,4
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China, 3Radiology, Case Western Reserve University, Cleveland, OH, United States, 4Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

A 3D MRF method was developed for T1 and T2 mapping of the entire monkey brain with high spatial resolution (0.35x0.35x1 mm3). A conformal head coil was used for improved SNR, which enabled a 24-fold acceleration in data acquisition. B1 inhomogeneity was corrected in dictionary matching. Comparison of the T1 and T2 maps showed a ~20% reduction of T2 in the globus pallidus of 6-year-old monkeys compared to 4-year-old monkeys.

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