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Abstract #2567

Early Adoptive Transfer of T Cells Decreases Brain Bleeding during Vesicular Stomatitis Virus Infection: A MRI Study

Li Liu1, Stephen Dodd1, Ryan Hunt1, Nikorn Pothayee1, Nadia Nadia Bouraoud1, Dragan Maric1, E Ashley Moseman1, Dorian B McGavern1, and Alan P Koretsky1
1National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, United States

MRI was used to follow bleeding and T cell infiltration in mouse model of nasal infection of the brain with VSV. Microbleeds were identified as an early pathological and neuroimaging marker using high-resolution T2*-weighted MRI. Adoptive transfer of virus specific CD8 T cells helped clear VSV, decreased microbleeds but did not stop all microbleeds. Labeling T cells with MPIOs enabled MRI cell tracking and showed the earliest T cell infiltration in the brain. CD8 T cell infiltration and vessel rupture happened 1-day post-infection at glomerular layer, while T cells could be detected at the center of bulb before vessel breakdown.

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