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Abstract #2568

Regional brain MRI features reveal the histological alterations in chronic pain: an MRI-based cell imaging study

Lei Wei1, Ming Ding1, Xiao Xiao1, and He Wang1,2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, shanghai, China, 2Human Phenome Institute, Fudan University, Shanghai, China, Shanghai, China

In our study, we used the ultra-high field magnetic imaging to show the brain functional and structure has changed in the rats of chronic pain model. then we also find the expression levels of the protein marker p-Erk has changed in some brain region, including insula, NAc, S1 and so on, and insula has been shown more significant activation. This results are same to the MRI functional data analysis. Finally, we hope to combine MRI and cell imaging technique could to verify the importance of insula in non-human chronic pain.

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