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Abstract #2571

Increased functional connectivity but intact memory performance in tauopathy mouse at pre-tangle stage

Ling-Yun Fan1, Hsu-Lei Lee1, Robert Sullivan1, Elizabeth Coulson1,2, Juan Carlos Polanco1,2, and Kai-Hsiang Chuang1,3
1Queensland Brain Institute, University of Queensland, St Lucia, Australia, 2Clem Jones Centre for Ageing Dementia Research, University of Queensland, St Lucia, Australia, 3Centre for Advanced Imaging, University of Queensland, St Lucia, Australia

Although pre-tangle stage of tauopathy is regarded as an important pathogenic factor in neurodegenerative disease, their relationship with brain functional connectivity (FC) is still ambiguous. We investigated a tau mouse (rTg4510) model at 2.5 month-old age by resting-state functional MRI, spatial memory task and histopathology. We found increased FC between hippocampus and medial temporal area in rTg4510. Moreover, increased FC is negatively related to learning performance even though the memory is intact. On pathology, there is little phosphorylated tau over temporal areas. Our results suggest FC alternation may be an early sign of neural dysfunction at pre-tangle stage.

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