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Abstract #2572

Spatio-temporal alterations in resting-state co-activation patterns in a rat model of sporadic Alzheimer’s disease

Yujian Diao1,2,3, Rolf Gruetter3, and Ileana O. Jelescu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Impaired brain glucose consumption is a possible trigger of Alzheimer’s disease (AD). Previous work revealed affected brain structure and function by insulin resistance in terms of altered static functional connectivity (FC) in an intracerebroventricular-streptozotocin (icv-STZ) rat model of AD. Here, we used the co-activation patterns (CAP) method, a dynamic FC approach, to assess differences between icv-STZ rats and healthy controls. STZ rats displayed early higher predominance of states involving brain regions shown as hyperconnected by the static FC analysis. Longitudinally, specific brain states declined in the STZ rats only.

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