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Abstract #2580

White Matter in Metachromatic Leukodystrophy as Assessed by Myelin Water Fraction and Diffusion Tensor Imaging

Laleh Eskandarian1,2, Safak Parlak3, Onur Afacan4,5, Ceren Günbey6, Nesibe Gevher Ertuğrul6, Banu Anlar6, and Kader Karli Oguz2,3
1Neuroscience Department, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 3Faculty of Medicine, Department of Radiology, Hacettepe University, Ankara, Turkey, 4Department of Radiology, Boston Children’s Hospital, Boston, MA, United States, 5Department of Radiology, Harvard Medical School, Boston, MA, United States, 6Department of Pediatrics, Hacettepe University, Ankara, Turkey

Metachromatic leukodystrophy (MLD) is a dysmyelinating autosomal recessive lysosomal storage disease. Conventional T2WI may not show the disease involvement accurately, especially in early phases of the disease where a bone marrow transplant can be a treatment option. Therefore we used Myelin Water Fraction (MWF) and Diffusion Tensor Imaging to investigate WM in patients with MLD. MWF and metrics derived from DTI, especially fractional anisotropy (FA), showed diffuse abnormality in WM and were significantly correlated. These imaging techniques can better assess involvement of the cerebral WM in patients with MLD.

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