Abstract #2581

Exploring edematous nerve fibers by using Neurite Orientation Dispersion and Density Imaging

Shin Tai Chong¹, Xinrui Liu², Hung-Wen Kao³, Chien-Yuan Eddy Lin⁴, Sanford PC Hsu⁵, and Ching-Po Lin¹

¹Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, ²Department of Neurosurgery, First Hospital of Jilin University, Jilin, China, ³Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ⁴GE Healthcare, Taipei, Taiwan, ⁵Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan

We hypothesized that the Neurite Orientation Dispersion and Density Imaging (NODDI)-based tractography could improve the reconstruction of the fiber tracts that by tracking through regions of peritumoral edema. In visual comparison with diffusion tensor imaging (DTI), we found that NODDI-based tractography of the corticospinal tract (CST) showed higher sensitivity and specificity in the region of peritumoral edema. The NODDI-based tractography was validated in two patients with tumors resected for five years. With this technique, neurosurgeons may develop better surgical planning to maximize tumor resection and minimize functional loss.

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