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Abstract #2581

Exploring edematous nerve fibers by using Neurite Orientation Dispersion and Density Imaging

Shin Tai Chong1, Xinrui Liu2, Hung-Wen Kao3, Chien-Yuan Eddy Lin4, Sanford PC Hsu5, and Ching-Po Lin1
1Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, 2Department of Neurosurgery, First Hospital of Jilin University, Jilin, China, 3Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 4GE Healthcare, Taipei, Taiwan, 5Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan

We hypothesized that the Neurite Orientation Dispersion and Density Imaging (NODDI)-based tractography could improve the reconstruction of the fiber tracts that by tracking through regions of peritumoral edema. In visual comparison with diffusion tensor imaging (DTI), we found that NODDI-based tractography of the corticospinal tract (CST) showed higher sensitivity and specificity in the region of peritumoral edema. The NODDI-based tractography was validated in two patients with tumors resected for five years. With this technique, neurosurgeons may develop better surgical planning to maximize tumor resection and minimize functional loss.

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