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Abstract #2584

Post-surgery network reorganization in glioma patients: a longitudinal study of functional segregation and centrality

Beatrice Federica Luciani1, Francesca Saviola1, Luca Zigiotto2,3, Stefano Tambalo1, Domenico ZacĂ 1, Lisa Novello1, Silvio Sarubbo2,3, and Jorge Jovicich1
1CIMeC Center for Mind/Brain Sciences, University of Trento, Rovereto (Trento), Italy, 2Department of Neuroscience, Division of Neurosurgery, S.Chiara Hospital, APSS, Trento, Italy, 3Structural and Functional Connectivity Lab, S.Chiara Hospital, APSS, Trento, Italy

In glioma patients, tumor lateralization and grade can critically affect the underlying brain functional connectivity. Little is known about how functional connectivity changes after surgical glioma resection. We employed graph theory analysis to investigate post-surgery longitudinal reorganization of functional networks at global (network-wide) and local (nodal) level. We found that left-lateralized and/or high-grade gliomas show reduced segregation and centrality properties over time, compared to right-lateralized and low-grade gliomas. Our results suggest the importance of pre-surgical mapping of hub networks like the default mode network, in addition to visual, motor and language networks.

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